Article
Simultaneous suppression of the MAP kinase and NF-κB pathways provides a robust therapeutic potential for thyroid cancer.
Cancer letters - 1 Nov 2015
Tsumagari Koji, Abd Elmageed Zakaria Y, Sholl Andrew B, Friedlander Paul, Abdraboh Mohamed, Xing Mingzhao, Boulares A Hamid, Kandil Emad
Abstract excerpt
The MAP kinase and NF-κB signaling pathways play an important role in thyroid cancer tumorigenesis. We aimed to examine the therapeutic potential of dually targeting the two pathways using AZD6244 and Bortezomib in combination. We evaluated their effects on cell proliferation, cell-cycle progression, apoptosis, cell migration assay, and the activation of the MAPK pathway in vitro and the in vivo using tumor size...
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