The Nuclear Factor Kappa-B Signaling Pathway as a Therapeutic Target Against Thyroid Cancers

Abstract excerpt

BACKGROUND: The nuclear factor kappa-B (NF-κB) proteins, a family of transcription factors found virtually in all cells, are known to play crucial roles in the growth of a number of human malignancies. The ability of NF-κB to target a large number of genes that regulate cell proliferation, differentiation, survival, and apoptosis, provides clues toward its deregulation during the process of tumorigenesis,...

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