Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exome sequencing reveals a nonsense mutation in TEX15 causing spermatogenic failure in a Turkish family.

Human molecular genetics - 1 Oct 2015

Okutman Ozlem, Muller Jean, Baert Yoni, Serdarogullari Munevver, Gultomruk Meral, Piton Amélie, Rombaut Charlotte, Benkhalifa Moncef, Teletin Marius, Skory Valerie, Bakircioglu Emre, Goossens Ellen, Bahceci Mustafa, Viville Stéphane

Abstract excerpt

Infertility is a global healthcare problem, and despite long years of assisted reproductive activities, a significant number of cases remain idiopathic. Our currently restricted understanding of basic mechanisms driving human gametogenesis severely limits the improvement of clinical care for infertile patients. Using exome sequencing, we identified a nonsense mutation leading to a premature stop in the TEX15...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Codon, Nonsense
Share to Consanguinity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infertility, Male

Share to Meiosis

Share to Oligospermia

Share to Organ Size

Share to Spermatogenesis

Share to Testis

Source

Identifiers

PMID: 26199321
DOI: 10.1093/hmg/ddv290

Genes

TEX15

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exome sequencing reveals a nonsense mutation in TEX15 causing spermatogenic failure in a Turkish family.PMID 26199321Read ↗

Two Novel TEX15 Mutations in a Family with Nonobstructive Azoospermia.Semantic proximity Read ↗

Genomic study of TEX15 variants: prevalence and allelic heterogeneity in men with spermatogenic failureSemantic proximity Read ↗

A Novel Compound Heterozygous Mutation in TEX14 Causes Human Non-Obstructive Azoospermia by Disrupting the Assembly of Intercellular Bridges.Semantic proximity Read ↗

TEX43, a Testis-Enriched Microtubule-Associated Gene, Exerts Minimal Impact on Spermatogenesis and Fertility in Mice and HumansSemantic proximity Read ↗

A new TEX11 mutation causes azoospermia and testicular meiotic arrest.Semantic proximity Read ↗

Scrutinizing the human TEX genes in the context of human male infertilitySemantic proximity Read ↗

Novel mutations of TEX11 are associated with non-obstructive azoospermia.Semantic proximity Read ↗

TENT5D disruption causes oligoasthenoteratozoospermia and male infertility.Semantic proximity Read ↗

Genetic variants in TEX15 gene conferred susceptibility to spermatogenic failure in the Chinese Han population.Semantic proximity Read ↗

Identification of TEX101-associated Proteins Through Proteomic Measurement of Human Spermatozoa Homozygous for the Missense Variant rs35033974*Semantic proximity Read ↗

Loss-of-function variant in TEX44 cause male infertility with asthenoteratozoospermia in humans and miceSemantic proximity Read ↗

Development of a novel next-generation sequencing panel for diagnosis of quantitative spermatogenic impairment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.