Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Novel Compound Heterozygous Mutation in TEX14 Causes Human Non-Obstructive Azoospermia by Disrupting the Assembly of Intercellular Bridges.

Clinical genetics - 1 Dec 2025

Li Guotong, Zhou Shushu, Li Yuqian, Atta Sana, Xia Xun, Sha Xuan, Hua Rong, Zhou Ping, Wei Zhaolian, Cao Yunxia, Wu Huan

Abstract excerpt

Intercellular bridges (ICBs) are critical in intercellular communication, coordinated cellular development, and the equilibration of cytoplasmic contents between germ cells during vertebrate spermatogenesis. Mammalian TEX14 is specifically expressed in the testes and is a pivotal component of ICBs. It is indispensable for proper spermatogenesis; its deficiency causes meiotic arrest at the pachytene stage of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Azoospermia
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterozygote

Share to Intercellular Junctions

Share to Meiosis

Share to Mutation

Share to Spermatogenesis

Share to Testis

Source

Identifiers

PMID: 40492599
DOI: 10.1111/cge.14783

Genes

TEX14

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Novel Compound Heterozygous Mutation in TEX14 Causes Human Non-Obstructive Azoospermia by Disrupting the Assembly of Intercellular Bridges.PMID 40492599Read ↗

Novel mutations of TEX11 are associated with non-obstructive azoospermia.Semantic proximity Read ↗

Two Novel TEX15 Mutations in a Family with Nonobstructive Azoospermia.Semantic proximity Read ↗

Expression analysis of genes encoding TEX11, TEX12, TEX14 and TEX15 in testis tissues of men with non-obstructive azoospermiaSemantic proximity Read ↗

Novel Hemizygous Mutations of TEX11 Cause Meiotic Arrest and Non-obstructive Azoospermia in Chinese Han PopulationSemantic proximity Read ↗

Deciphering the Molecular Characteristics of Human Idiopathic Nonobstructive Azoospermia from the Perspective of Germ CellsSemantic proximity Read ↗

Bi-allelic Mutations in M1AP Are a Frequent Cause of Meiotic Arrest and Severely Impaired Spermatogenesis Leading to Male Infertility.Semantic proximity Read ↗

Exome sequencing reveals a nonsense mutation in TEX15 causing spermatogenic failure in a Turkish family.Semantic proximity Read ↗

Genetic variants underlying spermatogenic arrests in men with non-obstructive azoospermiaSemantic proximity Read ↗

Novel MEIOB pathogenic variants including a homozygous non-canonical splicing variant, cause meiotic arrest and human non-obstructive azoospermia.Semantic proximity Read ↗

Genetic and functional analysis reveals novel mutations in meiotic genes underlying non-obstructive azoospermia.Semantic proximity Read ↗

<i>Tex11</i> Mutant Mouse Models of Human AzoospermiaSemantic proximity Read ↗

Genetic insights into non-obstructive azoospermia: Implications for diagnosis and TESE outcomesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.