Article
Human parvovirus B19 transgenic mice become susceptible to polyarthritis.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2004
Takasawa Naruhiko, Munakata Yasuhiko, Ishii Keiko Kumura, Takahashi Yuichi, Takahashi Minako, Fu Yi, Ishii Tomonori, Fujii Hiroshi, Saito Takako, Takano Hiroshi, Noda Tetsuo, Suzuki Misao, Nose Masato, Zolla-Patzner Suzan, Sasaki Takeshi
Abstract excerpt
Human parvovirus B19 (B19) often causes acute polyarthritis in adults. In this paper, we analyzed nucleotide sequences of the B19 genome of patients with rheumatoid arthritis (RA), and then introduced the nonstructural protein 1 (NS1) gene of B19 into C57BL/6 mice that had a genetic origin not susceptible to arthritis. The transgenic mice developed no lesions spontaneously, but were susceptible to type II...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.