Article
Effects of CYP3A5 polymorphism and the tacrolimus 12 h concentration on tacrolimus-induced acute renal dysfunction in patients with lupus nephritis.
Xenobiotica; the fate of foreign compounds in biological systems - 1 Jan 2015
Niioka Takenori, Komatsuda Atsushi, Kato Shotaro, Togashi Masaru, Okuyama Shin, Omokawa Ayumi, Nara Mizuho, Wakui Hideki, Takahashi Naoto, Miura Masatomo
Abstract excerpt
1. The purpose of the present study was to investigate the effect of tacrolimus concentration in blood 12 h after administration (C12h) on acute renal dysfunction in patients with lupus nephritis (LN) taking tacrolimus once daily. 2. Five of the 35 LN patients experienced tacrolimus-induced acute renal dysfunction. 3. The average annual C12h of tacrolimus was higher for patients with events of elevated serum...
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