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Article

ABCB1 genetic variant and its associated tacrolimus pharmacokinetics affect renal function in patients with rheumatoid arthritis.

Clinica chimica acta; international journal of clinical chemistry - 20 May 2015

Naito Takafumi, Mino Yasuaki, Aoki Yuki, Hirano Kumi, Shimoyama Kumiko, Ogawa Noriyoshi, Kagawa Yoshiyuki, Kawakami Junichi

Abstract excerpt

BACKGROUND: This study aimed to evaluate the blood exposure of and clinical responses to tacrolimus based on genetic variants of CYP3A5 and ABCB1 in patients with rheumatoid arthritis. METHODS: Seventy rheumatoid arthritis patients treated with oral tacrolimus once daily were enrolled. Blood conc...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25817604
DOI: 10.1016/j.cca.2015.03.021

Genes

ABCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25817604-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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