Article
Genome-wide association analysis on normal hearing function identifies PCDH20 and SLC28A3 as candidates for hearing function and loss.
Human molecular genetics - 1 Oct 2015
Vuckovic Dragana, Dawson Sally, Scheffer Deborah I, Rantanen Taina, Morgan Anna, Di Stazio Mariateresa, Vozzi Diego, Nutile Teresa, Concas Maria P, Biino Ginevra, Nolan Lisa, Bahl Aileen, Loukola Anu, Viljanen Anne, Davis Adrian, Ciullo Marina, Corey David P, Pirastu Mario, Gasparini Paolo, Girotto Giorgia
Abstract excerpt
Hearing loss and individual differences in normal hearing both have a substantial genetic basis. Although many new genes contributing to deafness have been identified, very little is known about genes/variants modulating the normal range of hearing ability. To fill this gap, we performed a two-stage meta-analysis on hearing thresholds (tested at 0.25, 0.5, 1, 2, 4, 8 kHz) and on pure-tone averages (low-, medium-...
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