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Article

Genetic causes of moderate to severe hearing loss point to modifiers.

Clinical genetics - 1 Apr 2017

Naz Sadaf, Imtiaz Ayesha, Mujtaba Ghulam, Maqsood Azra, Bashir Rasheeda, Bukhari Ihtisham, Khan Muhammad R, Ramzan Memoona, Fatima Amara, Rehman Atteeq U, Iqbal Muddassar, Chaudhry Taimur, Lund Merete, Brewer Carmen C, Morell Robert J, Friedman Thomas B

Abstract excerpt

The genetic underpinnings of recessively inherited moderate to severe sensorineural hearing loss are not well understood, despite its higher prevalence in comparison to profound deafness. We recruited 92 consanguineous families segregating stable or progressive, recessively inherited moderate or severe hearing loss. We utilized homozygosity mapping, Sanger sequencing, targeted capture of known deafness genes with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27573290
DOI: 10.1111/cge.12856
PMCID: PMC5365349

Genes

CLDN14
GJB2
OTOF
TMC1
TMPRSS3

Provenance

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