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Article

pH-Dependent interactions of human islet amyloid polypeptide segments with insulin studied by replica exchange molecular dynamics simulations.

The journal of physical chemistry. B - 12 Aug 2010

Jiang Ping, Wei Lei, Pervushin Konstantin, Mu Yuguang

Abstract excerpt

Amyloidogenesis of human islet amyloid polypeptide (hIAPP) within or surrounding secretory beta-cells of pancreas has long been related to the pathology of type II diabetes. Insulin, coexpressed and cosecreted with hIAPP in vivo, has the capacity of interacting with hIAPP and further inhibiting the amyloid deposition of the peptide. On the basis of the reported experimental data, we conducted replica exchange...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20684641
DOI: 10.1021/jp101811u

Genes

IAPP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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