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Article

Genomic alterations and possible druggable mutations in carcinoma of unknown primary (CUP).

Scientific reports - 23 Jul 2021

Es Hamidreza Aboulkheyr, Mahdizadeh Hamid, Asl Amir Abbas Hedayati, Totonchi Mehdi

Abstract excerpt

Carcinoma of Unknown Primary (CUP) is a heterogeneous and metastatic disease where the primary site of origin is undetectable. Currently, chemotherapy is the only state-of-art treatment option for CUP patients. The molecular profiling of the tumour, particularly mutation detection, offers a new treatment approach for CUP in a personalized fashion using targeted agents. We analyzed the mutation and copy number...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34302033
DOI: 10.1038/s41598-021-94678-4
PMCID: PMC8302572

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