Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic characterisation of molecular targets in carcinoma of unknown primary.

Journal of translational medicine - 4 Jul 2018

Clynick B, Dessauvagie B, Sterrett G, Harvey N T, Allcock R J N, Saunders C, Erber W, Meehan K

Abstract excerpt

BACKGROUND: Carcinoma of unknown primary (CUP) is a metastatic epithelial malignancy in the absence of an identifiable primary tumour. Prognosis for patients with CUP is poor because treatment options are generally limited to broad spectrum chemotherapy. A shift towards personalised cancer management based on mutation profiling offers the possibility of new treatment paradigms. This study has explored whether...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to HRAS gene
Share to MET gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MLH1 gene

Share to MYC gene

Share to Genetic Variation

Share to Molecular Targeted Therapy

Share to Neoplasms, Unknown Primary

Source

Open in PubMed Open full text

Identifiers

PMID: 29973234
DOI: 10.1186/s12967-018-1564-x
PMCID: PMC6032776

Genes

KRAS
MET
BRAF
EGFR
HRAS
MLH1
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic characterisation of molecular targets in carcinoma of unknown primary.PMID 29973234Read ↗

Genomic Alterations and Possible Druggable Mutations in Carcinoma of Unknown Primary (CUP)Semantic proximity Read ↗

Molecular driver alterations and their clinical relevance in cancer of unknown primary site.Semantic proximity Read ↗

Genomic alterations and possible druggable mutations in carcinoma of unknown primary (CUP).Semantic proximity Read ↗

Genomic Alterations and Possible Druggable Mutations in Carcinoma of Unknown Primary (CUP)Semantic proximity Read ↗

Cancers of Unknown Primary Origin: Real-World Clinical Outcomes and Genomic Analysis at the European Institute of Oncology.Semantic proximity Read ↗

Comprehensive Genomic Profiling of Carcinoma of Unknown Primary Site: New Routes to Targeted Therapies.Semantic proximity Read ↗

Genomic correlates of response and resistance to immune checkpoint inhibitors in carcinomas of unknown primary.Semantic proximity Read ↗

Cancer of unknown primary-Epidemiological trends and relevance of comprehensive genomic profiling.Semantic proximity Read ↗

Comprehensive Genomic Profiling of Carcinoma of Unknown Primary Origin: Retrospective Molecular Classification Considering the CUPISCO Study Design.Semantic proximity Read ↗

Cancer of unknown primary.Semantic proximity Read ↗

Baseline mutational profiles of patients with carcinoma of unknown primary origin enrolled in the CUPISCO study.Semantic proximity Read ↗

Does genomic profiling improve clinical outcome in carcinoma of unknown primary? - A systematic reviewSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.