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Article

Mosaic Epigenetic Inheritance as a Cause of Early-Onset Colorectal Cancer.

JAMA oncology - 1 Oct 2015

Sloane Mathew A, Nunez Andrea C, Packham Deborah, Kwok Chau-To, Suthers Graeme, Hesson Luke B, Ward Robyn L

Abstract excerpt

IMPORTANCE: Constitutional hypermethylation of 1 allele throughout the soma (constitutional epimutation) is an accepted mechanism of cancer predisposition. Understanding the origin and inheritance of epimutations is important for assessing cancer risk in affected families. OBSERVATIONS: We report a 29-year-old man with early-onset colorectal cancer who showed a constitutional MLH1 epimutation (approximately 50%...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26181641
DOI: 10.1001/jamaoncol.2015.1484

Genes

MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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