Article
A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice.
Science translational medicine - 18 Mar 2015
Tian Ying, Liu Ying, Wang Tao, Zhou Ning, Kong Jun, Chen Li, Snitow Melinda, Morley Michael, Li Deqiang, Petrenko Nataliya, Zhou Su, Lu Minmin, Gao Erhe, Koch Walter J, Stewart Kathleen M, Morrisey Edward E
Abstract excerpt
In contrast to lower vertebrates, the mammalian heart has limited capacity to regenerate after injury in part due to ineffective reactivation of cardiomyocyte proliferation. We show that the microRNA cluster miR302-367 is important for cardiomyocyte proliferation during development and is sufficient to induce cardiomyocyte proliferation in the adult and promote cardiac regeneration. In mice, loss of miR302-367...
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