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Article

NPY-Y1 coexpressed with NPY-Y5 receptors modulate anxiety but not mild social stress response in mice.

Genes, brain, and behavior - 1 Sept 2015

Longo A, Oberto A, Mele P, Mattiello L, Pisu M G, Palanza P, Serra M, Eva C

Abstract excerpt

The Y1 and Y5 receptors for neuropeptide Y have overlapping functions in regulating anxiety. We previously demonstrated that conditional removal of the Y1 receptor in the Y5 receptor expressing neurons in juvenile Npy1r(Y5R-/-) mice leads to higher anxiety but no changes in hypothalamus-pituitary-adrenocortical axis activity, under basal conditions or after acute restraint stress. In the present study, we used...

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Source

Identifiers

PMID: 26178014
DOI: 10.1111/gbb.12232

Genes

NPY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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