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Article

Conditional inactivation of neuropeptide Y Y1 receptors unravels the role of Y1 and Y5 receptors coexpressing neurons in anxiety.

Biological psychiatry - 1 Dec 2014

Longo Angela, Mele Paolo, Bertocchi Ilaria, Oberto Alessandra, Bachmann Alessia, Bartolomucci Alessandro, Palanza Paola, Sprengel Rolf, Eva Carola

Abstract excerpt

BACKGROUND: The Y1 receptor (Y1R) and Y5 receptor (Y5R) for neuropeptide Y share similar actions in the regulation of anxiety. Previously demonstrated that conditional removal of the Y1R during postnatal development in the forebrain excitatory neurons leads to higher anxiety, increased hypothalamus-pituitary-adrenocortical axis activity, and decreased body growth rate in male mice raised by foster mothers that...

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PMID: 24548641
DOI: 10.1016/j.biopsych.2014.01.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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