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Article

A Proline-Rich Domain in the Genotype 4 Hepatitis E Virus ORF3 C-Terminus Is Crucial for Downstream V105DLP108 Immunoactivity.

PloS one - 1 Jan 2015

Wang Heng, Ji Fangxiao, Liang Huanbin, Gu Honglang, Ning Zhangyong, Liu Rongchang, Zhang Guihong

Abstract excerpt

The hepatitis E virus (HEV) is responsible for serious viral hepatitis worldwide. Animals are considered a reservoir of HEV, particularly pigs. While HEV infection in pigs and dogs is always asymptomatic, the virus causes high death rates in patients with pre-existing chronic liver disease and pregnant women in developing countries. HEV open reading frame 2 (ORF2) has been used as a diagnostic target to detect...

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Identifiers

PMID: 26177202
DOI: 10.1371/journal.pone.0133282
PMCID: PMC4503470

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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