Article
Chromosomal position shift of a regulatory gene alters the bacterial phenotype.
Nucleic acids research - 30 Sept 2015
Gerganova Veneta, Berger Michael, Zaldastanishvili Elisabed, Sobetzko Patrick, Lafon Corinne, Mourez Michael, Travers Andrew, Muskhelishvili Georgi
Abstract excerpt
Recent studies strongly suggest that in bacterial cells the order of genes along the chromosomal origin-to-terminus axis is determinative for regulation of the growth phase-dependent gene expression. The prediction from this observation is that positional displacement of pleiotropic genes will affect the genetic regulation and hence, the cellular phenotype. To test this prediction we inserted the origin-proximal...
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