Article
Regulatory design governing progression of population growth phases in bacteria.
PloS one - 1 Jan 2012
Martínez-Antonio Agustino, Lomnitz Jason G, Sandoval Santiago, Aldana Maximino, Savageau Michael A
Abstract excerpt
It has long been noted that batch cultures inoculated with resting bacteria exhibit a progression of growth phases traditionally labeled lag, exponential, pre-stationary and stationary. However, a detailed molecular description of the mechanisms controlling the transitions between these phases is lacking. A core circuit, formed by a subset of regulatory interactions involving five global transcription factors...
Topics
- AraC Transcription Factor
- Chromosomes, Bacterial
- Colony Count, Microbial
- Computer Simulation
- DNA Replication
- Escherichia coli
- Escherichia coli Proteins
- Gene Expression Regulation, Bacterial
- Gene Regulatory Networks
- Genes, Bacterial
- Models, Genetic
- Phenotype
- Time Factors