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Article

Association between variant amyloid deposits and motor deficits in FAD-associated presenilin-1 mutations: A systematic review.

Neuroscience and biobehavioral reviews - 1 Sept 2015

Zhang Shuting, Lei Chunyan, Liu Peng, Zhang Mingming, Tao Wendan, Liu Hua, Liu Ming

Abstract excerpt

BACKGROUND: The variant amyloid deposits (VAD) include cotton wool plaques and diffuse plaques, which are associated with various motor deficits (e.g. spastic paraparesis, myoclonus, parkinsonism and ataxia). VADs have been repeatedly identified in presenilin 1 (PSEN1) mutations. It is still unknown the effect of VAD on the motor deficits as well as on the course of Alzheimer's disease (AD). METHODS: We conducted...

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Source

Identifiers

PMID: 26165445
DOI: 10.1016/j.neubiorev.2015.07.003

Genes

PSEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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