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Article

Variant Alzheimer's disease with spastic paraparesis: clinical characterization.

Neurology - 14 Mar 2000

Verkkoniemi A, Somer M, Rinne J O, Myllykangas L, Crook R, Hardy J, Viitanen M, Kalimo H, Haltia M

Abstract excerpt

OBJECTIVE: To present the clinical, neuroimaging, and electrophysiologic characteristics of a variant AD phenotype. BACKGROUND: The authors have identified a large Finnish kindred with presenile dementia and spastic paraparesis due to deletion of exon 9 of presenilin 1. Neuropathologic analysis showed unusual cortical "cotton wool" plaques, immunoreactive for the beta-amyloid peptide but lacking congophilic...

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Source

Identifiers

PMID: 10720282
DOI: 10.1212/wnl.54.5.1103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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