Comparison of clinical characteristics between familial and non-familial early onset Alzheimer's disease.

doi:10.1007/s00415-012-6481-y

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Article

Comparison of clinical characteristics between familial and non-familial early onset Alzheimer's disease.

Journal of neurology - 1 Oct 2012

Karve Simantini J, Ringman John M, Lee Albert S, Juarez Kevin O, Mendez Mario F

Abstract excerpt

Although familial Alzheimer's disease (FAD) is an early onset AD (EAD), most patients with EAD do not have a familial disorder. Recent guidelines recommend testing for genes causing FAD only in those EAD patients with two first-degree relatives. However, some patients with FAD may lack a known family history or other indications for suspecting FAD but might nonetheless be carriers of FAD mutations. The study was...

Topics

Adult
Age of Onset
Alzheimer Disease
Female
Humans
Male
Middle Aged
Mutation
Presenilin-1
Retrospective Studies

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Open in PubMed Open full text

Identifiers

PMID: 22460587
DOI: 10.1007/s00415-012-6481-y
PMCID: PMC3442121

Genes

PSEN1

Provenance

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