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Article

Variable phenotype of Alzheimer's disease with spastic paraparesis.

Journal of neurochemistry - 1 Feb 2008

Karlstrom Helena, Brooks William S, Kwok John B J, Broe G Anthony, Kril Jillian J, McCann Heather, Halliday Glenda M, Schofield Peter R

Abstract excerpt

Pedigrees with familial Alzheimer's disease (AD) show considerable phenotypic variability. Spastic paraparesis (SP), or progressive spasticity of the lower limbs is frequently hereditary and exists either as uncomplicated (paraparesis alone) or complicated (paraparesis and other neurological features) disease subtypes. In some AD families, with presenilin-1 (PSEN1) mutations, affected individuals also have SP....

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Share to PSEN1 gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Paraparesis, Spastic

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Share to Plaque, Amyloid

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Source

Identifiers

PMID: 17995932
DOI: 10.1111/j.1471-4159.2007.05038.x

Genes

PSEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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