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Article

Potential role of hypoxia in early stages of Hodgkin lymphoma pathogenesis.

Haematologica - 1 Oct 2015

Wein Frederik, Otto Teresa, Lambertz Pascal, Fandrey Joachim, Hansmann Martin-Leo, Küppers Ralf

Abstract excerpt

A unique feature of the germinal center B cell-derived Hodgkin and Reed/Sternberg cells of classical Hodgkin lymphoma is their lost B cell phenotype and the aberrant expression of factors of other hematopoietic cell types, including ID2 and NOTCH1. As cellular dedifferentiation and upregulation of ID2 and NOTCH1 are typical consequences of a hypoxic response, we wondered whether hypoxia may impose an HRS...

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Topics

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Share to B-Lymphocytes
Share to Germinal Center
Share to Hodgkin Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia

Share to Hypoxia-Inducible Factor 1

Share to Intercellular Signaling Peptides and Proteins

Share to Lymphoma, Large B-Cell, Diffuse

Share to Neoplasm Staging

Source

Open in PubMed Open full text

Identifiers

PMID: 26160878
DOI: 10.3324/haematol.2015.127498
PMCID: PMC4591764

Genes

NOTCH1
DUSP1
JUN
PCGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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