Article
ALDH1A1-overexpressing cells are differentiated cells but not cancer stem or progenitor cells in human hepatocellular carcinoma.
Oncotarget - 22 Sept 2015
Tanaka Kaori, Tomita Hiroyuki, Hisamatsu Kenji, Nakashima Takayuki, Hatano Yuichiro, Sasaki Yoshiyuki, Osada Shinji, Tanaka Takuji, Miyazaki Tatsuhiko, Yoshida Kazuhiro, Hara Akira
Abstract excerpt
Aldehyde dehydrogenase 1A1 (ALDH1A1) is considered to be a cancer stem cell marker in several human malignancies. However, the role of ALDH1A1 in hepatocellular carcinoma (HCC) has not been well elucidated. In this study, we investigated the relationship between ALDH1A1 and clinicopathological findings and examined whether ALDH1A1 deserves to be a cancer stem cell marker in HCC. Sixty HCC samples obtained from...
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