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Article

Cutting Edge: Redox Signaling Hypersensitivity Distinguishes Human Germinal Center B Cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2015

Polikowsky Hannah G, Wogsland Cara E, Diggins Kirsten E, Huse Kanutte, Irish Jonathan M

Abstract excerpt

Differences in the quality of BCR signaling control key steps of B cell maturation and differentiation. Endogenously produced H2O2 is thought to fine tune the level of BCR signaling by reversibly inhibiting phosphatases. However, relatively little is known about how B cells at different stages sense and respond to such redox cues. In this study, we used phospho-specific flow cytometry and high-dimensional mass...

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Share to B-Lymphocyte Subsets
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 6

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Source

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Identifiers

PMID: 26157177
DOI: 10.4049/jimmunol.1500904
PMCID: PMC4530023

Genes

BCR
SYK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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