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Article

Extended in vitro maturation affects gene expression and DNA methylation in bovine oocytes.

Molecular human reproduction - 1 Oct 2015

Heinzmann Julia, Mattern Felix, Aldag Patrick, Bernal-Ulloa Sandra Milena, Schneider Tamara, Haaf Thomas, Niemann Heiner

Abstract excerpt

To mimic post-ovulatory ageing, we have extended the in vitro maturation (IVM) phase to 48 h and examined effects on (i) developmental potential, (ii) expression of a panel of developmentally important genes and (iii) gene-specific epigenetic marks. Results were compared with the 24 h IVM protocol (control) usually employed for bovine oocytes. Cleavage rates and blastocyst yields were significantly reduced in...

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Identifiers

PMID: 26155800
DOI: 10.1093/molehr/gav040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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