Article
The Paraoxonase 1 Gene c.-108C>T SNP in the Promoter Is Associated with Risk for Glioma in Mexican Patients, but Not the p.L55M or p.Q192R Polymorphisms in the Coding Region.
Genetic testing and molecular biomarkers - 1 Sept 2015
González-Herrera Lizbeth, Gamas-Trujillo Pablo Alejandro, Medina-Escobedo Gilberto, Oaxaca-Castillo David, Pérez-Mendoza Gerardo, Williams-Jacquez Dayana, Canto-Cetina Thelma, Vargas-García Rubén Darío
Abstract excerpt
AIM: To evaluate the association of the paraoxonase 1 (PON1) gene polymorphisms c.-108C>T, p.L55M, and p.Q192R with the risk of glioma in Southeast Mexico. Decreased PON1 activity caused by polymorphisms has been observed in gliomas, thus supporting the theory that PON1 is involved in tumorigenesis in the brain. METHODS: Sixty-seven glioma patients and 58 control individuals were included. Three PON1...
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