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Article

CD4+ and CD8+ T cells contribute to psoriasis phenotype when integrated into human skin equivalents for drug testing.

Frontiers in immunology - 1 Jan 2026

Vahav Irit, Thon Maria, Koning Jasper J, Gibbs Susan, Thiel Andreas, Loyal Lucie

Abstract excerpt

The limited translational potential of experimental animal models for human skin disease pathophysiology demands the development of more suitable immunocompetent human experimental models. Psoriasis ranks among the most prevalent human inflammatory skin disorders, initiated and manifested by the interplay of T cells with epidermal keratinocytes. Current in vitro models recapitulate psoriasis-like pathology by...

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Share to CD4-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42039187
DOI: 10.3389/fimmu.2026.1790531
PMCID: PMC13106556

Genes

CD4
CCL20
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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