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Article

MDM2 Amplification in Problematic Lipomatous Tumors: Analysis of FISH Testing Criteria.

The American journal of surgical pathology - 1 Oct 2015

Clay Michael R, Martinez Anthony P, Weiss Sharon W, Edgar Mark A

Abstract excerpt

To discriminate lipomas from atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) we perform fluorescence in situ hybridization (FISH) for MDM2 amplification in several problematic situations: "lipomas" >10 cm, lesions with equivocal atypia, recurrent "lipomas," all retroperitoneal/pelvic/abdominal "lipomas", and in cases not fitting the above criteria but having worrisome clinical or radiologic...

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Share to Diagnosis, Differential
Share to Gene Amplification

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization, Fluorescence

Share to Lipoma

Share to Neoplasm Recurrence, Local

Share to Predictive Value of Tests

Share to Proto-Oncogene Proteins c-mdm2

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Source

Identifiers

PMID: 26146760
DOI: 10.1097/PAS.0000000000000468

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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