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MDM2 RNA In Situ Hybridization for the Diagnosis of Atypical Lipomatous Tumor

5 Dec 2018

Abstract excerpt

The distinction of atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) from its benign counterpart, lipoma, may represent a challenge. MDM2 DNA amplification is used as the gold standard as MDM2 immunohistochemistry lacks specificity and sensitivity. Herein, we investigate the diagnostic utility of MDM2 RNA in situ hybridization (RNA-ISH) and compare the test with MDM2 immunohistochemistry and...

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PMID: 30520819
DOI: 10.1097/pas.0000000000001199

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