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Article

Transcriptome and ultrastructural changes in dystrophic Epidermolysis bullosa resemble skin aging

14 Jun 2015

Abstract excerpt

The aging process of skin has been investigated recently with respect to mitochondrial function and oxidative stress. We have here observed striking phenotypic and clinical similarity between skin aging and recessive dystrophic Epidermolysis bullosa (RDEB), which is caused by recessive mutations in the gene coding for collagen VII,COL7A1. Ultrastructural changes, defects in wound healing, and inflammation markers...

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PMID: 26143532
DOI: 10.18632/aging.100755

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