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Article

Differential recruitment of UBQLN2 to nuclear inclusions in the polyglutamine diseases HD and SCA3.

Neurobiology of disease - 1 Oct 2015

Zeng Li, Wang Bo, Merillat Sean A, Minakawa Eiko N, Perkins Matthew D, Ramani Biswarathan, Tallaksen-Greene Sara J, Costa Maria do Carmo, Albin Roger L, Paulson Henry L

Abstract excerpt

Accumulation of mutant polyglutamine proteins in intraneuronal inclusions is a hallmark of polyglutamine diseases. Impairment of protein clearance systems and sequestration of clearance-related proteins into inclusions occur in many protein folding diseases, including polyglutamine diseases. The ubiquitin-binding and proteasome adaptor protein UBQLN2 participates in protein homeostasis and localizes to inclusions...

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Source

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Identifiers

PMID: 26141599
DOI: 10.1016/j.nbd.2015.06.017
PMCID: PMC4642276

Genes

UBQLN2
ATXN3
HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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