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Article

Rare double sex and mab-3-related transcription factor 1 regulatory variants in severe spermatogenic failure.

Andrology - 1 Sept 2015

Lima A C, Carvalho F, Gonçalves J, Fernandes S, Marques P I, Sousa M, Barros A, Seixas S, Amorim A, Conrad D F, Lopes A M

Abstract excerpt

The double sex and mab-3-related transcription factor 1 (DMRT1) gene has long been linked to sex-determining pathways across vertebrates and is known to play an essential role in gonadal development and maintenance of spermatogenesis in mice. In humans, the genomic region harboring the DMRT gene cluster has been implicated in disorders of sex development and recently DMRT1 deletions were shown to be associated...

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Source

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Identifiers

PMID: 26139570
DOI: 10.1111/andr.12063
PMCID: PMC4802187

Genes

DMRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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