Article
Cross talk between TP53 and c-Myc in the pathophysiology of Diamond-Blackfan anemia: Evidence from RPL11-deficient in vivo and in vitro models.
Biochemical and biophysical research communications - 8 Jan 2018
Chakraborty Anirban, Uechi Tamayo, Nakajima Yukari, Gazda Hanna T, O'Donohue Marie-Françoise, Gleizes Pierre-Emmanuel, Kenmochi Naoya
Abstract excerpt
Mutations in genes encoding ribosomal proteins have been identified in Diamond-Blackfan anemia (DBA), a rare genetic disorder that presents with a prominent erythroid phenotype. TP53 has been implicated in the pathophysiology of DBA with ribosomal protein (RP) L11 playing a crucial role in the TP53 response. Interestingly, RPL11 also controls the transcriptional activity of c-Myc, an oncoprotein that positively...
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