Article
Ribosomal protein L11 mutation in zebrafish leads to haematopoietic and metabolic defects.
British journal of haematology - 1 Jan 2011
Danilova Nadia, Sakamoto Kathleen M, Lin Shuo
Abstract excerpt
Mutations in ribosomal proteins are associated with a congenital syndrome, Diamond-Blackfan anaemia (DBA), manifested by red blood cell aplasia, developmental abnormalities and increased risk of malignancy. Recent studies suggest the involvement of p53 activation in DBA. However, which pathways are involved and how they contribute to the DBA phenotype remains unknown. Here we show that a zebrafish mutant for the...
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