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Article

Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys

3 Jul 2015

Abstract excerpt

Preclinical studies of viral vector-based HIV-1 vaccine candidates have previously shown partial protection against neutralization-resistant virus challenges in rhesus monkeys. In this study, we evaluated the protective efficacy of adenovirus serotype 26 (Ad26) vector priming followed by purified envelope (Env) glycoprotein boosting. Rhesus monkeys primed with Ad26 vectors expressing SIVsmE543 Env, Gag, and Pol...

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PMID: 26138104
DOI: 10.1126/science.aab3886

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