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Sequential use of Ad26-based vaccine regimens in NHP to induce immunity against different disease targets

15 Nov 2022

Abstract excerpt

The adenovirus (Ad)26 serotype-based vector vaccine Ad26.COV2.S has been used in millions of subjects for the prevention of COVID-19, but potentially elicits persistent anti-vector immunity. We investigated if vaccine-elicited immunity to Ad26 vector-based vaccines significantly influences antigen-specific immune responses induced by a subsequent vaccination with Ad26 vector-based vaccine regimens against...

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PMID: 36379957
DOI: 10.1038/s41541-022-00567-w

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