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Impact of CYP1A2 and CYP2D6 Polymorphisms on Drug Metabolism and on Insulin and Lipid Elevations and Insulin Resistance in Clozapine-Treated Patients

15 May 2007

Abstract excerpt

OBJECTIVE: Adverse metabolic effects of atypical antipsychotics have increasingly been recognized. Recently, we found that levels of insulin and triglycerides increased by increasing serum clozapine concentration in clozapine-treated patients. As these insulin and triglyceride elevations probably are drug concentration-dependent, they also would be expected to be drug metabolism-related. The genetically...

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PMID: 17503978
DOI: 10.4088/jcp.v68n0506

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