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Article

Metabolic stress induces a Wnt-dependent cancer stem cell-like state transition

2 Jul 2015

Abstract excerpt

Reciprocal interactions between cancer cells and the tumor microenvironment drive multiple clinically significant behaviors including dormancy, invasion, and metastasis as well as therapy resistance. These microenvironment-dependent phenotypes share typical characteristics with cancer stem cells (CSC). However, it is poorly understood how metabolic stress in the confined tumor microenvironment contributes to the...

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Identifiers

PMID: 26136078
DOI: 10.1038/cddis.2015.171

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