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Article

Parkinson's disease-associated ATP13A2/PARK9 functions as a lysosomal H+,K+-ATPase.

Nature communications - 20 Apr 2023

Fujii Takuto, Nagamori Shushi, Wiriyasermkul Pattama, Zheng Shizhou, Yago Asaka, Shimizu Takahiro, Tabuchi Yoshiaki, Okumura Tomoyuki, Fujii Tsutomu, Takeshima Hiroshi, Sakai Hideki

Abstract excerpt

Mutations in the human ATP13A2 (PARK9), a lysosomal ATPase, cause Kufor-Rakeb Syndrome, an early-onset form of Parkinson's disease (PD). Here, we demonstrate that ATP13A2 functions as a lysosomal H+,K+-ATPase. The K+-dependent ATPase activity and the lysosomal K+-transport activity of ATP13A2 are inhibited by an inhibitor of sarco/endoplasmic reticulum Ca2+-ATPase, thapsigargin, and K+-competitive inhibitors of...

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Identifiers

PMID: 37080960
DOI: 10.1038/s41467-023-37815-z
PMCID: PMC10119128

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