Article
An overproduction of astellolides induced by genetic disruption of chromatin-remodeling factors in Aspergillus oryzae.
The Journal of antibiotics - 1 Jan 2016
Shinohara Yasutomo, Kawatani Makoto, Futamura Yushi, Osada Hiroyuki, Koyama Yasuji
Abstract excerpt
The filamentous fungus Aspergillus oryzae is an important industrial mold. Recent genomic analysis indicated that A. oryzae has a large number of biosynthetic genes for secondary metabolites (SMs), but many of the SMs they produce have not been identified. For better understanding of SMs production by A. oryzae, we screened a gene-disruption library of transcription factors including chromatin-remodeling factors...
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