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Article

Histone deacetylase activity regulates chemical diversity in Aspergillus.

Eukaryotic cell - 1 Sept 2007

Shwab E Keats, Bok Jin Woo, Tribus Martin, Galehr Johannes, Graessle Stefan, Keller Nancy P

Abstract excerpt

Bioactive small molecules are critical in Aspergillus species during their development and interaction with other organisms. Genes dedicated to their production are encoded in clusters that can be located throughout the genome. We show that deletion of hdaA, encoding an Aspergillus nidulans histone deacetylase (HDAC), causes transcriptional activation of two telomere-proximal gene clusters--and subsequent...

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Identifiers

PMID: 17616629
DOI: 10.1128/EC.00186-07
PMCID: PMC2043372

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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