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Article

Discovery of McrA, a master regulator of Aspergillus secondary metabolism.

Molecular microbiology - 1 Jan 2017

Oakley C Elizabeth, Ahuja Manmeet, Sun Wei-Wen, Entwistle Ruth, Akashi Tomohiro, Yaegashi Junko, Guo Chun-Jun, Cerqueira Gustavo C, Russo Wortman Jennifer, Wang Clay C C, Chiang Yi-Ming, Oakley Berl R

Abstract excerpt

Fungal secondary metabolites (SMs) are extremely important in medicine and agriculture, but regulation of their biosynthesis is incompletely understood. We have developed a genetic screen in Aspergillus nidulans for negative regulators of fungal SM gene clusters and we have used this screen to isolate mutations that upregulate transcription of the non-ribosomal peptide synthetase gene required for nidulanin A...

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Identifiers

PMID: 27775185
DOI: 10.1111/mmi.13562
PMCID: PMC5218965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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