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Article

Genetic and Functional Evidence Supports LPAR1 as a Susceptibility Gene for Hypertension.

Hypertension (Dallas, Tex. : 1979) - 1 Sept 2015

Xu Ke, Ma Lu, Li Yang, Wang Fang, Zheng Gu-Yan, Sun Zhijun, Jiang Feng, Chen Yundai, Liu Huirong, Dang Aimin, Chen Xi, Chun Jerold, Tian Xiao-Li

Abstract excerpt

Essential hypertension is a complex disease affected by genetic and environmental factors and serves as a major risk factor for cardiovascular diseases. Serum lysophosphatidic acid correlates with an elevated blood pressure in rats, and lysophosphatidic acid interacts with 6 subtypes of receptors. In this study, we assessed the genetic association of lysophosphatidic acid receptors with essential hypertension by...

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Source

Identifiers

PMID: 26123684
DOI: 10.1161/HYPERTENSIONAHA.115.05515

Genes

LPAR1
LPAR2
LPAR3
LPAR4
LPAR5
LPAR6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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