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Article

KRAS and aneusomy of chromosomes 4, 10 and 12 in colorectal carcinomas.

Pathology, research and practice - 1 Sept 2015

Beyer Kristin, Altendorf-Hofmann Annelore, Chen Yuan, Bickel Klaus, Petersen Iver

Abstract excerpt

AIMS: KRAS mutation status has predictive significance in EGFR-antibody treatment of colorectal adenocarcinoma. The aim of the study was the evaluation of KRAS mutation status in correlation to KRAS copy numbers and ploidy status. METHODS: Colorectal adenocarcinomas (n=52) were assembled into a TMA and analyzed by FISH. Probes for centromeres 4 and 10 were applied as surrogate markers for the ploidy status. In...

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Source

Identifiers

PMID: 26122820
DOI: 10.1016/j.prp.2015.05.008

Genes

KRAS
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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