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Article

A FOXM1 Dependent Mesenchymal-Epithelial Transition in Retinal Pigment Epithelium Cells.

PloS one - 1 Jan 2015

Choudhary Parul, Dodsworth Benjamin Thomas, Sidders Ben, Gutteridge Alex, Michaelides Christos, Duckworth Joshua Kane, Whiting Paul John, Benn Caroline Louise

Abstract excerpt

The integrity of the epithelium is maintained by a complex but regulated interplay of processes that allow conversion of a proliferative state into a stably differentiated state. In this study, using human embryonic stem cell (hESC) derived Retinal Pigment Epithelium (RPE) cells as a model; we have investigated the molecular mechanisms that affect attainment of the epithelial phenotype. We demonstrate that RPE...

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Source

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Identifiers

PMID: 26121260
DOI: 10.1371/journal.pone.0130379
PMCID: PMC4488273

Genes

FOXM1
RPE
BMP7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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