Article
Evolutionary stalling and a limit on the power of natural selection to improve a cellular module.
Proceedings of the National Academy of Sciences of the United States of America - 4 Aug 2020
Venkataram Sandeep, Monasky Ross, Sikaroodi Shohreh H, Kryazhimskiy Sergey, Kacar Betul
Abstract excerpt
Cells consist of molecular modules which perform vital biological functions. Cellular modules are key units of adaptive evolution because organismal fitness depends on their performance. Theory shows that in rapidly evolving populations, such as those of many microbes, adaptation is driven primarily by common beneficial mutations with large effects, while other mutations behave as if they are effectively neutral....
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