Article
Cerebral oxygen and glucose metabolism in patients with mitochondrial m.3243A>G mutation.
Brain : a journal of neurology - 1 Dec 2009
Lindroos Markus M, Borra Ronald J, Parkkola Riitta, Virtanen Sami M, Lepomäki Virva, Bucci Marco, Virta Jere R, Rinne Juha O, Nuutila Pirjo, Majamaa Kari
Abstract excerpt
The m.3243A>G mutation is the most common pathogenic mutation in mitochondrial DNA. It leads to defective oxidative phosphorylation, decreased oxygen consumption and increased glucose utilization and lactate production in vitro. However, oxygen and glucose metabolism has not been studied in the brain of patients harbouring the m.3243A>G mutation. Therefore, 14 patients with the m.3243A>G mutation, not...
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