Article
EGF-Induced Acetylation of Heterogeneous Nuclear Ribonucleoproteins Is Dependent on KRAS Mutational Status in Colorectal Cancer Cells.
PloS one - 1 Jan 2015
Roda Desamparados, Castillo Josefa, Telechea-Fernández Marcelino, Gil Anabel, López-Rodas Gerardo, Franco Luís, González-Rodríguez Patricia, Roselló Susana, Pérez-Fidalgo J Alejandro, García-Trevijano Elena R, Cervantes Andrés, Zaragozá Rosa
Abstract excerpt
KRAS mutational status is considered a negative predictive marker of the response to anti-EGFR therapies in colorectal cancer (CRC) patients. However, conflicting data exist regarding the variable response to EGFR-targeted therapy. The effects of oncogenic KRAS on downstream targets were studied in cell lines with different KRAS mutations. Cells harboring a single KRASG13D allele showed the most tumorigenic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.